The maker of computer chips will take a $1.2bn charge to cover restructuring costs.
The job cuts, about 11% of Intel's workforce, will be made over the next 12 months,Intel said in a statement.
Intel said it wants to "accelerate evolution from a PC company to one that powers the cloud and billions of smart, connected computing devices".
The company also said on Tuesday chief financial officer Stacy Smith would move to a new role leading sales, manufacturing and operations.
Intel said it would begin a formal search process for a successor.
Shares in the company were down 2.5% in after-hours trading on Wall Street. Intel's stock price had already fallen 8.4% this year.
(BBC News)