Polls open at 07:00 BST at around 50,000 polling stations across the country,BBC reports.
A total of 650 Westminster MPs will be elected, with about 50 million people registered to vote.
As well as the general election, there are more than 9,000 council seats being contested across 279 English local authorities.
Mayors will also be elected in Bedford, Copeland, Leicester, Mansfield, Middlesbrough and Torbay.
This means that nearly every voter in England - excluding London where there are no local elections - will be given at least two ballot papers when they enter polling stations.
Some votes have already been cast, through postal voting, which accounted for 15% of the total electorate at the 2010 general election, when the overall turnout was 65%.
For the first time, people have been able to register to vote online.
Most polling stations are in schools, community centres and parish halls, but pubs, a launderette and a school bus will also be used.
A handful of seats are expected to be declared by midnight, with the final results expected on Friday afternoon.
Polls close at 22:00 BST, but officials say anyone in a polling station queue at this time should be able to cast their vote.
Three individuals with Sri Lankan origin, Chamila Fernando, Ranil Jayawardena and Uma Kumaran, are also to contest in this election.
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