Messi finally matched Telmo Zarra's 251 goals with a fantastic free-kick, having failed to score in his last three La Liga matches.
Sevilla levelled through a Jordi Alba own goal, but Neymar made it 2-1.

Ivan Rakitic scored a header before Messi's record breaker from a counter-attack and goal number 253 came after a one-two with Neymar.

The 27-year-old's goal tally is all the more remarkable given his goals have come in only 250 starts for Barcelona.

Earlier in the month, Messi drew level with Raul's all-time Champions League record of 71 goals after scoring twice in Barcelona's 2-0 victory against Ajax.