Police stopped a convoy of 75 vehicles, carrying over 250 persons including women, on Andhra Pradesh-Tamil Nadu border near Sullurpet in the district.
The protesters, carrying placards and flags, shouted slogans against Rajapaksa before heading back to Tamil Nadu, said Deputy Superintendent of Police B Srinivas.
Andhra police have tightened security in the border areas. The roads leading Tirupati from Tamil Nadu have been closed.
Rajapaksa arrived in Tirupati by a special flight this afternoon. He is slated to offer prayers at the famous Tirumala temple there early tomorrow morning.
"A full-fledged security arrangement has been made. Rajapaksa is scheduled to fly back to Sri Lanka tomorrow after offering prayers to Lord Balaji," Deputy Superintendent of Police Ravishankar Reddy told PTI.
(PTI)