The Wimbledon and US Open winning player and his partner will walk down the aisle in Dunblane Cathedral at about 16:00.
The couple, both 27, will say their vows at the 12th Century cathedral before heading to a small reception for family members and close friends.
Many fans and well-wishers are expected to turn out in the central Scotland town to mark the occasion.
Bunting has been put up along the town's high street, while local shops havededicated window displays to the big day. Some residents have planned garden parties.
In the early hours, Murray sent a tweet, made up of emoticons, which depicts the day ahead for him and his bride.
Starting with sunshine and showers, it then shows nails being painted, hair being done, a church, a ring, a kiss, a camera, food, a cake, drinks, music, dancing, the moon, hearts and zzzzzz.
(BBC News)