It is the first time the broadcaster has hired a woman for the position.
Ms Guthrie joined Google in 2011 and is currently working in the technology giant's offices in Singapore.
ABC said her experience included working with various media firms, including Foxtel, BskyB and Star.
The former media lawyer is set to take over from Mark Scott in April.
Mr Scott, who has headed up ABC since 2006, announced his departure earlier this year. He was responsible for introducing News 24 to the ABC and oversaw a large range of big cuts to the broadcaster's budget.
-BBC